Long-Term Side-Effects of Seroquel and Concerta

"My son with Asperger's is currently on Seroquel and Concerta. I would like to know the long-term side effects of these medications."

Just as a precursor to this question (as it covers medication), I need to point out that I am not a doctor or medically trained individual and any information in this article is for information purposes only. You must seek appropriate medical advice from an approved health care practitioner for medical diagnosis and treatment.

O.K., boring legal jargon out of the way, so let’s get on with the article …

Seroquel is an antipsychotic medication that changes the chemical activity within the brain. It treats the symptoms of schizophrenia and bipolar disorder (manic depression), which are psychotic disorders. Be aware that the following is a comprehensive list of possible reactions to Seroquel. It is rare that most or all of these symptoms will occur.

As with most other medications, there are side effects when taking Seroquel. This medication might cause high blood sugar, diabetes, and suicidal thoughts. Also, Seroquel might cause impairment of thoughts or reactions to external events, and it is not recommended to take Seroquel if you are going to operate a motor vehicle. Another side effect of Seroquel includes adverse reactions if alcohol is consumed.

Please be careful if you are also taking medicine for colds/allergies, sleeping pills, muscle relaxants, or antidepressants. You can become sleepy if Seroquel interacts with these medications. You will need to contact an emergency medical facility if the following reactions occur: difficulty breathing, hives, swelling of the face, lips, tongue, or throat. Call your doctor at once if you have any new or worse symptoms such as: mood or behaviour changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts of suicide or hurting yourself.

Concerta is widely known to be a medication that treats Attention-Deficit Hyperactivity Disorder (ADHD). While Concerta offers a number of advantages over pre-existing ADHD medications, it has side effects that you should know about.

Concerta is taken once a day because it is a timed-release medication. It comes in capsule form, and it has an outer coating of medication that quickly dissolves when swallowed. The medicinal effect of Concerta lasts twelve hours, and the following need to be considered when taking this medication:

• It should be taken in the morning hours. If a dose is skipped, wait until the following day; otherwise, your sleep/wake cycle will be affected.
• A dose of Concerta cannot be adjusted. Any change in milligrams must be done with a new prescription. 
• A Concerta capsule cannot be mixed with food; this will prevent the proper release of the medication.
• Concerta is not recommended for people with digestive problems.

A comprehensive list of Concerta side effects includes: abdominal pain aggravation, aggression, anxiety, depression, hostility, insomnia and prolonged sleepiness, loss of appetite, increased coughing, nervousness, sadness, drug dependence, dizziness, headache, tics, sinusitis, upper respiratory tract infection, vomiting, allergic reactions, increased blood pressure, and psychosis.

Concerta is not recommended for children under the age of six. Also, Concerta may be habit forming.

Best Comments:

Anonymous said...
I would like to add something to this as well...our son (4 yrs old, high functioning Aspergers) tried Concerta for the first time yesterday...and tho we were warned about possible "letdown" effects; when the medication is done after the 12 hrs, usually starting at 10-11 hrs...It was a nightmare! Now NOT all kids are going to experience these issues, however if your dr has not warned you, please be aware. Needless to say, this med is a no-go for our son :-/ I wish everyone luck, as this med has done wonders for some...just not our little Aspie.

Anonymous said...
I believe there CAN BE some serious long term affects of seroquel, but they are rare. Seroquel is very sedating...which may be something your looking for is sleep is an issue. Have you tried risperdal? Or abilify? Abilify works great for my aspie and little to no side affects. Concerta was a nightmare for us as were all stimulants. Abilify has helped slow him down enough that he can focus alot better. But I know of no long term affect from concerta.

Anonymous said...
We do ambilify and rispidone with our high aspie 13 year old. Works great but we've been having to give him double the dose of rispidone when he has an evening event like scouts or soccer. The only side effect is weight gain and sometimes trouble sleeping. But we are happy with the results overall.

Anonymous said...
My 12 year old aspie boy (also diagnosed with O.D.D. and O.C.D.) is currently on valproic acid. He has tried concerta in the past -when he was 7...it increased his anxiety, caused him to be overly focused on what he was already worried or obsessed about, and paranoid (almost hallucinating). Tried seroquel around age 9...caused rapid weight gain and sedative...without really addressing his symptoms effectively. We have also tried him on risperdal (caused him to be more obsessive, agitated); clomipramine, zoloft, dexadrine (stimulant kept him awake all night) luvox...to name a few. We have never found something that is extremely effective at addressing his main symptoms. If anyone has any suggestions of what has worked with their child I would appreciate your input. The main symptoms we would like to alleviate are anxiety (school and social), obsessions (extreme preoccupation with body image, hair, face, etc) depression, without weight gain or serious side effects. Thank you.

Anonymous said...
My 5 yr old who has only ADHD takes concerta and srtaterra. He does fine on those two. My 7 yr old Aspie takes straterra for his ADHD and rispadol. No problems.

Anonymous said...
My 9 year old son has been on Concerta XL for a year now. The only side affect is loss of appitite - which we were warned about. It isn't too much of a problem as he eats in the evening and when he has a day off it.

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ASD and Anxiety Overload

"What can I do as a parent to help my Asperger's child to be less anxious about his upcoming trip to the zoo? His 5th grade class will be going on this field trip next week, and he is very nervous about it."

Autism Spectrum Disorders (ASD) and anxiety go hand-in-hand. It affects a child’s ability to communicate with others or to understand the world around him, and that’s bound to cause anxiety and panic sometimes. Anxiety becomes even worse when there is a change in the ASD child’s routine. Even positive and “fun” changes, like a school field trip or a visit to the zoo, can increase anxiety and aggressive behaviors. The renowned autism expert Tony Atwood is fond of putting it this way: “Autism is anxiety looking for a target.”

For parents, the best course of action is to anticipate upcoming changes and help your child prepare for them. Many parents find it helpful to use stories and pictures to prepare children for impending disruptions. If it’s a field trip to the zoo, for example, use pictures to show your child what he’ll see at the zoo, what the zoo will be like, and what sort of things to expect. Do this each day for three or four days prior to the trip. That way, when the trip actually happens, the child won’t be entirely out of his element, but will already understand and appreciate some of what will be happening.

Other changes in the routine are less enjoyable but still necessary. Getting a new teacher can be traumatic, as can moving to a new house. If at all possible, try to spread out the major changes. If you move to a new house, try to do it during the summer, so that your child won’t have to deal with the added anxiety of getting a new school and new teacher mid-year.

You can also introduce your child to the concept of “change” in a positive way by practicing with non-negative things. For example, just for practice, give him a little extra TV time instead of homework time one night, to show that changes in the routine can often be fun and good. Then practice with a neutral change (homework after dinner instead of before dinner), then with a negative one (changing play time into chore time). This process can help your child grow accustomed to the idea of change and learn to adapt without becoming anxious.

For continual, ongoing anxiety, many parents have begun using anti-anxiety medications for their ASD children. Usually, the medications are selective serotonin reuptake inhibitors (SSRIs), and are also used for obsessive-compulsive disorder and depression. Prozac, Luvox, Zoloft and Anafranil are all common for anxiety in children with ASD.

All children with ASD are different. You and your doctor should monitor your child’s progress very closely, using the lowest dose of medication possible, to see what improvements it makes and whether there are any adverse reactions.

Medication should be the last resort for ASD, not the first one. There are a number of natural remedies available if you don’t want to go down the drug route. But try behavioral and dietary modifications first, to see what improvements can be made naturally.

The Parenting Autism Resource Guide: A Complete Resource Guide For Parents Who Have Children Diagnosed With Autism

Dealing With Your Child's Frustrations

"I would like ideas on how to deal with my Aspergers son’s frustrations. He will either dig his heels in and refuse to do what he is supposed to do, or he shuts down and then we have a time away so he can get himself together to discuss the problem. It seems he works himself up over things that are not that big a deal."

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Asperger's Syndrome: Quick Facts

Asperger’s Syndrome is:

• a complex brain disorder that falls within the Autism spectrum
• a developmental condition in which people have difficulties understanding how to interact socially
•  a mild variation of autism; however, individuals with Asperger's Syndrome have normal intelligence and language development
• a neurological disorder with symptoms similar to those of “classic” autism
• a pervasive developmental disorder characterized by persistent impairments in social interaction, restricted development and repetitive patterns of behavior, interests, and activities
• an autistic spectrum disorder characterized by difficulties with social interaction, motor delays, adherence to routines, average to above-average intelligence, and preoccupation with a particular subject of interest
• called a syndrome because the cause is not known, but it does describes how a person thinks, feels, and acts as a human being
• characterized as being at the mildest and highest functioning end of the spectrum, or Pervasive Developmental Disorder Continuum
• is a developmental disorder in which people have severe difficulties understanding how to interact socially
• the same diagnosis as Autism, except it explicitly states no retardation or speech problems
• typically associated with poor social behavior
• very hard to diagnosis

Children with Asperger’s Syndrome:

• are often isolated because of their poor social skills and narrow interests
• are often the target of bullying at school due to their unusual behavior, language, interests, and impaired ability to perceive and respond in socially expected ways to nonverbal cues, particularly in interpersonal conflict
• display motor delays, clumsiness, and problems with social interaction
• have difficulty with social interactions and understanding unspoken social cues
• have traits that make them appear to be perfectionists
• have trouble interacting with their peers, but can carry on an intelligent and often animated conversation with adult
• may appear to be physically clumsy
• may be extremely literal and may have difficulty interpreting and responding to sarcasm or banter
• may talk at length about a favorite subject or repeat a word or phrase over and over again
• often have difficulty with transitions or changes and prefer sameness
• often have limited and very focused interests
• often mature more slowly
• often show a stilted or bouncy walk, which appears awkward
• struggle with a problem and internalize their feelings until their emotions boil over, leading to a complete meltdown
• take verbal and written communication literally
• tend to be self-absorbed, have difficulty making friends, are often preoccupied with their own interests and easily become the victims of teasing or bullying
• typically develop a good to excellent vocabulary, but they usually lack the social instincts and practical skills needed for relating to others
• typically exhibit distinct awkwardness when in just about any kind of social setting, as well as an all-absorbing interest in specific topics or subjects, utilizing intense focus
• typically make efforts to establish friendships, but they may have difficulty making friends because of their social awkwardness
• usually have a history of developmental delays in motor skills, such as pedaling a bike, catching a ball, or climbing outdoor play equipment
• usually have excellent memories, especially in the area of facts, figures, dates, times and statistics
• want to know everything about their topic of interest and their conversations with others will be about little else

Applied Behavioral Analysis

"I've heard that ABA therapy is very effective for children with high functioning autism. Is this true, and how does it work?"

It is often difficult to understand why the child with Asperger's or High-Functioning Autism behaves the way he does. However, there is a reason for his behavior, and Applied Behavior Analysis (ABA) helps us understand the behavior and determine a method of support for the child so that he no longer needs the behavior to meet his needs.

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